My daughter has an atypical form of eczema known as dyshydrotic eczema. It presents as small bumps underneath the skin on the palms (and sometimes feet) that itch horribly. It is generally connected to food allergies and intolerances. Oddly enough, she never had the problem before we began cutting foods out, and we have yet to figure out which food is the culprit.
The majority of her scratching occurs at night during her sleep. The worst spot is in between her tumbs and forefingers, where she rubs her thumbs against the skin on her fingers. In order to help her sleep better, I knitted some wrist warmers for her to wear at night after she puts her cream on. They seem to help keep her from scratching as much.